Age Dependent Dysfunction of Mitochondrial and ROS Metabolism Induced by Mitonuclear Mismatch

Age Dependent Dysfunction of Mitochondrial and ROS Metabolism Induced by Mitonuclear Mismatch

Mitochondrial and nuclear genomes have to coevolve to ensure the proper functioning of the different mitochondrial complexes that are assembled from peptides encoded by both genomes. Mismatch between these genomes is believed to be strongly selected against due to the consequent impairments of mitoc...

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Bibliographic Details
Main Authors: Nicolas Pichaud, Roxanne Bérubé, Geneviève Côté, Claude Belzile, France Dufresne, Geneviève Morrow, Robert M. Tanguay, David M. Rand, Pierre U. Blier
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Genetics
Subjects:
aging
Drosophila
mitochondrial respiration
mitonuclear incompatibility
reactive oxygen species
replication
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00130/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00130/full

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