Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia

Besides dopamine-deficiency related motor symptoms, nonmotor symptoms, including cognitive changes occur in Parkinson's disease (PD) patients, that may relate to accumulation of α-synuclein in the hippocampus (HC). This brain region also contains stem cells that can proliferate. This is a well-...

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Bibliographic Details
Main Authors: Karlijn J. Doorn, Benjamin Drukarch, Anne-Marie van Dam, Paul J. Lucassen
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2014/959154