Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies

Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies

Abstract Background The circadian clock governs a large variety of fundamentally important physiological processes in all three domains of life. Consequently, asynchrony in timekeeping mechanisms could give rise to cellular dysfunction underpinning many disease pathologies including human neoplasms....

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Bibliographic Details
Main Authors: Wai Hoong Chang, Alvina G. Lai
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Translational Medicine
Subjects:
Circadian clock
Hypoxia
Oncogene
Tumour suppressor
Gain-of-function
Loss-of-function
Online Access:http://link.springer.com/article/10.1186/s12967-019-1880-9

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http://link.springer.com/article/10.1186/s12967-019-1880-9

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