Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation

Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation

Objective: T cell activation triggers metabolic reprogramming to meet increased demands for energy and metabolites required for cellular proliferation. Ethanolamine phospholipid synthesis has emerged as a regulator of metabolic shifts in stem cells and cancer cells, which led us to investigate its p...

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Bibliographic Details
Main Authors: Chi Ma, FuKun W. Hoffmann, Michael P. Marciel, Kathleen E. Page, Melodie A. Williams-Aduja, Ellis N.L. Akana, Greg S. Gojanovich, Mariana Gerschenson, Johann Urschitz, Stefan Moisyadi, Vedbar S. Khadka, Sharon Rozovsky, Youping Deng, F. David Horgen, Peter R. Hoffmann
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Molecular Metabolism
Subjects:
Selenium
Selenoprotein
Phosphatidylethanolamine
Ethanolamine phosphotransferase
Metabolic sensing
AMPK
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000107

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http://www.sciencedirect.com/science/article/pii/S2212877821000107

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