Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats.

Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats.

The molecular mechanism linking aldosterone and endothelin-1 in the development of diabetic nephropathy has not been completely elucidated. Here, we provide evidence showing that streptozotocin-induced diabetic rats have significantly increased aldosterone and endothelin-1 in the kidney tissue and m...

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Bibliographic Details
Main Authors: Qiaoling Zhou, Kanghan Liu, Hongyu Wu, Lihe Chen, Veeraragoo Pouranan, Mingxia Yuan, Zhou Xiao, Weisheng Peng, Ao Xiang, Rong Tang, Wenzheng Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3471839?pdf=render

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http://europepmc.org/articles/PMC3471839?pdf=render

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