Bacterially Derived Tryptamine Increases Mucus Release by Activating a Host Receptor in a Mouse Model of Inflammatory Bowel Disease

Bacterially Derived Tryptamine Increases Mucus Release by Activating a Host Receptor in a Mouse Model of Inflammatory Bowel Disease

Summary: Recent studies emphasize the role of microbial metabolites in regulating gastrointestinal (GI) physiology through activation of host receptors, highlighting the potential for inter-kingdom signaling in treating GI disorders. In this study, we show that tryptamine, a tryptophan-derived bacte...

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Bibliographic Details
Main Authors: Yogesh Bhattarai, Si Jie, David R. Linden, Sayak Ghatak, Ruben A.T. Mars, Brianna B. Williams, Meng Pu, Justin L. Sonnenburg, Michael A. Fischbach, Gianrico Farrugia, Lei Sha, Purna C. Kashyap
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Rodent Gastroenterology
Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220309950

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http://www.sciencedirect.com/science/article/pii/S2589004220309950

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