CDCA2 promotes the proliferation of colorectal cancer cells by activating the AKT/CCND1 pathway in vitro and in vivo

CDCA2 promotes the proliferation of colorectal cancer cells by activating the AKT/CCND1 pathway in vitro and in vivo

Abstract Background Cell division cycle associated 2 (CDCA2), upregulated in lung adenocarcinoma and oral squamous cell carcinoma, may be related to some malignant diseases. Nevertheless, its role in colorectal cancer (CRC) remains unknown. Methods CDCA2 expression was analyzed using The Cancer Geno...

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Bibliographic Details
Main Authors: Yifei Feng, Wenwei Qian, Yue Zhang, Wen Peng, Jie Li, Qiou Gu, Dongjian Ji, Zhiyuan Zhang, Qingyuan Wang, Dongsheng Zhang, Yueming Sun
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Cancer
Subjects:
CDCA2
CCND1
Proliferation
PI3K/AKT pathway
Colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s12885-019-5793-z

Internet

http://link.springer.com/article/10.1186/s12885-019-5793-z

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