Deferiprone and Gallium-Protoporphyrin Have the Capacity to Potentiate the Activity of Antibiotics in Staphylococcus aureus Small Colony Variants

Deferiprone and Gallium-Protoporphyrin Have the Capacity to Potentiate the Activity of Antibiotics in Staphylococcus aureus Small Colony Variants

Small colony variants (SCVs) of bacteria like Staphylococcus aureus are characterized by a reduced colony size and are linked to increased antibiotic tolerance and resistance. Their altered expression of virulence factors, slow growing properties and their ability to form biofilms make the eradicati...

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Bibliographic Details
Main Authors: Katharina Richter, Nicky Thomas, Guimin Zhang, Clive A. Prestidge, Tom Coenye, Peter-John Wormald, Sarah Vreugde
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
biofilms
small colony variants
Staphylococcus aureus
iron
deferiprone
gallium-protoporphyrin
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00280/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00280/full

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