Structural analysis of HIV-1 maturation using cryo-electron tomography.

Structural analysis of HIV-1 maturation using cryo-electron tomography.

HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious virion requires proteolytic cleavage of the Gag polyprotein at five positions, leading to a dramatic change in virus morphology. Immature virions contain an incomplete spherical shell where Gag is arran...

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Bibliographic Details
Main Authors: Alex de Marco, Barbara Müller, Bärbel Glass, James D Riches, Hans-Georg Kräusslich, John A G Briggs
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2999899?pdf=render

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http://europepmc.org/articles/PMC2999899?pdf=render

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