Exact Distribution of Linkage Disequilibrium in the Presence of Mutation, Selection, or Minor Allele Frequency Filtering

Exact Distribution of Linkage Disequilibrium in the Presence of Mutation, Selection, or Minor Allele Frequency Filtering

Linkage disequilibrium (LD), often expressed in terms of the squared correlation (r2) between allelic values at two loci, is an important concept in many branches of genetics and genomics. Genetic drift and recombination have opposite effects on LD, and thus r2 will keep changing until the effects o...

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Bibliographic Details
Main Authors: Jiayi Qu, Stephen D. Kachman, Dorian Garrick, Rohan L. Fernando, Hao Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Genetics
Subjects:
linkage disequilibrium
effective population size
mutation rate
selection
minor allele frequency filtering
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00362/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00362/full

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