Age-related increase in caveolin-1 expression facilitates cell-to-cell transmission of α-synuclein in neurons

Abstract Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, with aging being considered the greatest risk factor for developing PD. Caveolin-1 (Cav-1) is known to participate in the aging process. Recent evidence indicates that prion-like propagation of misfolded α...

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Bibliographic Details
Main Authors: Tae-Young Ha, Yu Ree Choi, Hye Rin Noh, Seon-Heui Cha, Jae-Bong Kim, Sang Myun Park
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Molecular Brain
Subjects:
Online Access:https://doi.org/10.1186/s13041-021-00834-2