A novel human 3D lung microtissue model for nanoparticle-induced cell-matrix alterations

A novel human 3D lung microtissue model for nanoparticle-induced cell-matrix alterations

Abstract Background Multi-walled carbon nanotubes (MWCNT) have been shown to elicit the release of inflammatory and pro-fibrotic mediators, as well as histopathological changes in lungs of exposed animals. Current standards for testing MWCNTs and other nanoparticles (NPs) rely on low-throughput in v...

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Bibliographic Details
Main Authors: Pranita K. Kabadi, April L. Rodd, Alysha E. Simmons, Norma J. Messier, Robert H. Hurt, Agnes B. Kane
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Particle and Fibre Toxicology
Subjects:
Three-dimensional spheroids
Human lung microtissues
Nanoparticles
Cell-matrix interactions
In vitro testing methods
Multi-walled carbon nanotubes
Online Access:http://link.springer.com/article/10.1186/s12989-019-0298-0

Internet

http://link.springer.com/article/10.1186/s12989-019-0298-0

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