Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions

Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions

The mechanism that leads to liquid-liquid phase separation (LLPS) of the tau protein, whose pathological aggregation is implicated in neurodegenerative disorders, is not well understood. Establishing a phase diagram that delineates the boundaries of phase co-existence is key to understanding whether...

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Bibliographic Details
Main Authors: Yanxian Lin, James McCarty, Jennifer N Rauch, Kris T Delaney, Kenneth S Kosik, Glenn H Fredrickson, Joan-Emma Shea, Songi Han
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
tau
liquid-liquid phase separation
phase diagram
field-theoretic simulations
complex coacervation
Alzheimer's disease
Online Access:https://elifesciences.org/articles/42571

Internet

https://elifesciences.org/articles/42571

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