Combinatory antibiotic treatment protects against experimental acute pancreatitis by suppressing gut bacterial translocation to pancreas and inhibiting NLRP3 inflammasome pathway

Combinatory antibiotic treatment protects against experimental acute pancreatitis by suppressing gut bacterial translocation to pancreas and inhibiting NLRP3 inflammasome pathway

Gut bacterial translocation following impaired gut barrier is a critical determinant of initiating and aggravating acute pancreatitis (AP). Antibiotic combination (ABX; vancomycin, neomycin and polymyxin b) is capable of reducing gut bacteria, but its efficacy in AP prevention and the underlying mec...

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Bibliographic Details
Main Authors: Lingling Jia, Hao Chen, Jun Yang, Xin Fang, Wenying Niu, Ming Zhang, Jiahong Li, Xiaohua Pan, Zhengnan Ren, Jia Sun, Li-Long Pan
Format: Article
Language:English
Published: SAGE Publishing 2020-01-01
Series:Innate Immunity
Online Access:https://doi.org/10.1177/1753425919881502

Internet

https://doi.org/10.1177/1753425919881502

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