Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation

Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation

Parkin and PINK1 are involved in damaged mitochondria clearance; however the sequence of events of Parkin activation is not clear. Here, the authors show that binding to phospho-ubiquitin on mitochondria enables Parkin phosphorylation, which allows Repressor Element of Parkin removal, E3 ligase acti...

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Main Authors: Matthew Y. Tang, Marta Vranas, Andrea I. Krahn, Shayal Pundlik, Jean- François Trempe, Edward A. Fon
Format: Article
Language:English
Published: Nature Publishing Group 2017-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14697
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spelling doaj-b55f87d3a9934780bd5addb22763e47c2021-05-11T07:15:06ZengNature Publishing GroupNature Communications2041-17232017-03-018111410.1038/ncomms14697Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activationMatthew Y. Tang0Marta Vranas1Andrea I. Krahn2Shayal Pundlik3Jean- François Trempe4Edward A. Fon5Department of Neurology and Neurosurgery, McGill Parkinson Program, Neurodegenerative Diseases Group, Montreal Neurological Institute, McGill UniversityDepartment of Pharmacology and Therapeutics, Groupe de Recherche Axé sur la Structure des Protéines, McGill UniversityDepartment of Neurology and Neurosurgery, McGill Parkinson Program, Neurodegenerative Diseases Group, Montreal Neurological Institute, McGill UniversityDepartment of Neurology and Neurosurgery, McGill Parkinson Program, Neurodegenerative Diseases Group, Montreal Neurological Institute, McGill UniversityDepartment of Pharmacology and Therapeutics, Groupe de Recherche Axé sur la Structure des Protéines, McGill UniversityDepartment of Neurology and Neurosurgery, McGill Parkinson Program, Neurodegenerative Diseases Group, Montreal Neurological Institute, McGill UniversityParkin and PINK1 are involved in damaged mitochondria clearance; however the sequence of events of Parkin activation is not clear. Here, the authors show that binding to phospho-ubiquitin on mitochondria enables Parkin phosphorylation, which allows Repressor Element of Parkin removal, E3 ligase activation and mitophagy.https://doi.org/10.1038/ncomms14697
collection DOAJ
language English
format Article
sources DOAJ
author Matthew Y. Tang
Marta Vranas
Andrea I. Krahn
Shayal Pundlik
Jean- François Trempe
Edward A. Fon
spellingShingle Matthew Y. Tang
Marta Vranas
Andrea I. Krahn
Shayal Pundlik
Jean- François Trempe
Edward A. Fon
Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
Nature Communications
author_facet Matthew Y. Tang
Marta Vranas
Andrea I. Krahn
Shayal Pundlik
Jean- François Trempe
Edward A. Fon
author_sort Matthew Y. Tang
title Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
title_short Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
title_full Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
title_fullStr Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
title_full_unstemmed Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
title_sort structure-guided mutagenesis reveals a hierarchical mechanism of parkin activation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-03-01
description Parkin and PINK1 are involved in damaged mitochondria clearance; however the sequence of events of Parkin activation is not clear. Here, the authors show that binding to phospho-ubiquitin on mitochondria enables Parkin phosphorylation, which allows Repressor Element of Parkin removal, E3 ligase activation and mitophagy.
url https://doi.org/10.1038/ncomms14697
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AT shayalpundlik structureguidedmutagenesisrevealsahierarchicalmechanismofparkinactivation
AT jeanfrancoistrempe structureguidedmutagenesisrevealsahierarchicalmechanismofparkinactivation
AT edwardafon structureguidedmutagenesisrevealsahierarchicalmechanismofparkinactivation
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