Split-Doa10: a naturally split polytopic eukaryotic membrane protein generated by fission of a nuclear gene.

Large polytopic membrane proteins often derive from duplication and fusion of genes for smaller proteins. The reverse process, splitting of a membrane protein by gene fission, is rare and has been studied mainly with artificially split proteins. Fragments of a split membrane protein may associate an...

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Bibliographic Details
Main Authors: Elisabeth Stuerner, Shigehiro Kuraku, Mark Hochstrasser, Stefan G Kreft
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3464245?pdf=render