Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer

Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer

Chromosomal instability not only has a negative effect on survival in triple-negative breast cancer, but also on the well treatable subgroup of luminal A tumors. This suggests a general mechanism independent of subtypes. Increased chromosomal instability (CIN) in triple-negative breast cancer (TNBC)...

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Bibliographic Details
Main Authors: Felix Meyer, Saskia Becker, Sandra Classen, Ann Christin Parplys, Wael Yassin Mansour, Britta Riepen, Sara Timm, Claudia Ruebe, Maria Jasin, Harriet Wikman, Cordula Petersen, Kai Rothkamm, Kerstin Borgmann
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
triple-negative breast cancer (tnbc)
chromosomal instability (cin)
cin70 score
homologous recombination (hr)
dna-damage response (ddr)
chk1
Online Access:https://www.mdpi.com/2073-4409/9/1/238

Internet

https://www.mdpi.com/2073-4409/9/1/238

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