α(δ')-Michael Addition of Alkyl Amines to Dimethyl (E)-hex-2-en-4-ynedioate: Synthesis of α,β-Dehydroamino Acid Derivatives

α(δ')-Michael Addition of Alkyl Amines to Dimethyl (E)-hex-2-en-4-ynedioate: Synthesis of α,β-Dehydroamino Acid Derivatives

The direct nucleophilic addition of alkyl amines to the α(δ')-carbon atom of dimethyl (E)-hex-2-en-4-ynedioate to generate α,β-dehydroamino acid derivatives is reported. Herein, we have studied the reactivity of various primary and secondary alkyl amines in the α-selective nucleophilic conj...

Full description

Bibliographic Details
Main Authors: Jie-Cheng Deng, Arjun S. Chavan, Shih-Ching Chuang
Format: Article
Language:English
Published: MDPI AG 2013-02-01
Series:Molecules
Subjects:
α-Michael addition
conjugated enyne
dehydroamino acids
Online Access:http://www.mdpi.com/1420-3049/18/3/2611

Internet

http://www.mdpi.com/1420-3049/18/3/2611

Similar Items