Pretreatment with nimodipine reduces incidence of POCD by decreasing calcineurin mediated hippocampal neuroapoptosis in aged rats

Pretreatment with nimodipine reduces incidence of POCD by decreasing calcineurin mediated hippocampal neuroapoptosis in aged rats

Abstract Background Calcineurin (CaN) having a high expression in hippocampal neurons is closely related to apoptosis. Pretreatment with nimodipine can lower the apoptosis rate of hippocampal neuron to reduce the incidence of postoperative cognitive dysfunction (POCD). However, the relationship betw...

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Bibliographic Details
Main Authors: Qi Zhang, Yanan Li, Yongjuan Bao, Chunping Yin, Xi Xin, Yangyang Guo, Fang Gao, Shuping Huo, Xiuli Wang, Qiujun Wang
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Anesthesiology
Subjects:
Nimodipine
Calcineurin
Aged
POCD
Online Access:http://link.springer.com/article/10.1186/s12871-018-0501-0

Internet

http://link.springer.com/article/10.1186/s12871-018-0501-0

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