Tricky Topology: Persistence of Folded Human Telomeric i-Motif DNA at Ambient Temperature and Neutral pH

i-Motifs are four-stranded DNA structures formed from sequences rich in cytosine, held together by hemi-protonated cytosine-cytosine base pairs. These structures have been utilized extensively as pH-switches in DNA-based nanotechnology. Recently there has been an increasing interest in i-motif struc...

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Bibliographic Details
Main Authors: Mahmoud A. S. Abdelhamid, Zoë A. E. Waller
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Chemistry
Subjects:
DNA
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00040/full