Stability of Epidoxorubicin Hydrochloride in Aqueous Solutions: Experimental and Theoretical Studies

Stability of Epidoxorubicin Hydrochloride in Aqueous Solutions: Experimental and Theoretical Studies

The first-order degradation kinetics of epidoxorubicin were investigated as a function of pH, temperature, and buffers concentrations. The degradation was followed by HPLC. Buffer catalysis was observed in acetate and phosphate buffers. The pH-rate profiles were obtained at 333, 343, 353, and 363 K....

Full description

Bibliographic Details
Main Authors:	Agnieszka Sobczak, Monika A. Lesniewska-Kowiel, Izabela Muszalska, Artur Firlej, Judyta Cielecka-Piontek, Szymon Tomczak, Bolesław Barszcz, Irena Oszczapowicz, Anna Jelińska
Format:	Article
Language:	English
Published:	Hindawi Limited 2017-01-01
Series:	Journal of Chemistry
Online Access:	http://dx.doi.org/10.1155/2017/8107140

Similar Items

The Influence of pH and Temperature on the Stability of N-[(Piperidine)methylene]daunorubicin Hydrochloride and a Comparison of the Stability of Daunorubicin and Its Four New Amidine Derivatives in Aqueous Solutions
by: Mikołaj Piekarski, et al.
Published: (2014-01-01)

Tricyclic Derivative of Acyclovir and Its Esters in Relation to the Esters of Acyclovir Enzymatic Stability: Enzymatic Stability Study
by: Izabela Muszalska-Kolos, et al.
Published: (2020-05-01)

Development and validation of the stability-indicating LC-UV method for the determination of cefoselis sulphate
by: Zalewski Przemysław, et al.
Published: (2012-02-01)

Radiolytic studies of cefozopran hydrochloride in the solid state
by: Przemysław Zalewski, et al.
Published: (2017-01-01)

Application of Vibrational Spectroscopy Supported by Theoretical Calculations in Identification of Amorphous and Crystalline Forms of Cefuroxime Axetil
by: Alicja Talaczyńska, et al.
Published: (2015-01-01)

Combinations of Freeze-Dried Amorphous Vardenafil Hydrochloride with Saccharides as a Way to Enhance Dissolution Rate and Permeability
by: Gabriela Wiergowska, et al.
Published: (2021-05-01)

Radiation Sterilization of Anthracycline Antibiotics in Solid State
by: A. Kaczmarek, et al.
Published: (2013-01-01)

Drug-induced diabetes type 2: In silico study involving class B GPCRs.
by: Dorota Latek, et al.
Published: (2019-01-01)

Potential off-target effects of beta-blockers on gut hormone receptors: In silico study including GUT-DOCK-A web service for small-molecule docking.
by: Pawel Pasznik, et al.
Published: (2019-01-01)

Virtual Screening of <i>C. Sativa</i> Constituents for the Identification of Selective Ligands for Cannabinoid Receptor 2
by: Mikołaj Mizera, et al.
Published: (2020-07-01)

Fixed-Dose Combination of NSAIDs and Spasmolytic Agents in the Treatment of Different Types of Pain—A Practical Review
by: Magdalena Janczura, et al.
Published: (2021-07-01)

Co-Administration of Drugs and Parenteral Nutrition: In Vitro Compatibility Studies of Loop Diuretics for Safer Clinical Practice
by: Szymon Tomczak, et al.
Published: (2020-11-01)

Amorphous Form of Carvedilol Phosphate—The Case of Divergent Properties
by: Szymon Sip, et al.
Published: (2021-09-01)

<i>Cannabis sativa</i> L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment
by: Anna Stasiłowicz, et al.
Published: (2021-01-01)

Intereactions between doripenem and clavulanate — Application of minimal inhibitory concentration analysis and cytometry flow for bactericidal studies
by: Katarzyna Ciemniak, et al.
Published: (2018-03-01)

Machine Learning Approach for Determining the Formation of β-Lactam Antibiotic Complexes with Cyclodextrins Using Multispectral Analysis
by: Mikołaj Mizera, et al.
Published: (2019-02-01)

Studies on the stability of cocaine hydrochloride in aqueous solutions
by: Al-Shoura, Hasan I.
Published: (1976)

Hydrophilic interaction chromatography (HILIC) for the determination of cetirizine dihydrochloride
by: Magdalena Paczkowska, et al.
Published: (2019-12-01)

Application of the HPLC Method in Parenteral Nutrition Assessment: Stability Studies of Ondansetron
by: Szymon Tomczak, et al.
Published: (2021-03-01)

Equilibrium in the System of Glauconite – Aqueous Solution of Cefepime Hydrochloride
by: Tatiana A. Krysanova, et al.
Published: (2019-12-01)

Physico-chemical studies on promethazine hydrochloride in aqueous solution
by: Stevens, J.
Published: (1973)

Aqueous solution of poly (hexamethylene guanidine hydrochloride) and poly (diethylenamine guanidine hydrochloride) as studied with acid-base indicators
by: Anastasia Yu. Kharchenko, et al.
Published: (2019-12-01)

Meropenem – therapeutic recommendation after twenty years of presence on pharmaceutical market
by: Magdalena Paczkowska, et al.
Published: (2014-05-01)

Structural Polymorphism of Sorafenib Tosylate as a Key Factor in Its Solubility Differentiation
by: Gabriela Wiergowska, et al.
Published: (2021-03-01)

Chitosan as Valuable Excipient for Oral and Topical Carvedilol Delivery Systems
by: Szymon Sip, et al.
Published: (2021-07-01)

Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids
by: Czarniak P, et al.
Published: (2016-03-01)

Regioselective iodination of activated arenes using KI-DMSO in aqueous hydrochloride
by: Sainath Zangade, et al.
Published: (2021-01-01)

Analysis of the Composition of Lyophilisates Obtained from <i>Aloe arborescens</i> Gel of Leaves of Different Ages from Controlled Crops
by: Kamil Pawłowicz, et al.
Published: (2021-05-01)

Role of Curcumin and (−)-Epigallocatechin-3-<i>O</i>-Gallate in Bladder Cancer Treatment: A Review
by: Ludwika Piwowarczyk, et al.
Published: (2020-07-01)

Preparation of Beebread Caviar from Buckwheat Honey through Immobilization with Sodium Alginate
by: Małgorzata Smuga-Kogut, et al.
Published: (2020-09-01)

Can Cranberry Juice Protect against Rotenone-Induced Toxicity in Rats?
by: Monika Kurpik, et al.
Published: (2021-03-01)

Comprehensive spectral identification of key intermediates to the final product of the chiral pool synthesis of radezolid
by: Katarzyna Michalska, et al.
Published: (2017-08-01)

Design of Paracetamol Delivery Systems Based on Functionalized Ordered Mesoporous Carbons
by: Joanna Goscianska, et al.
Published: (2020-09-01)

Computer-Aided Discovery of New Solubility-Enhancing Drug Delivery System
by: Mikołaj Mizera, et al.
Published: (2020-06-01)

Amine-Grafted Mesoporous Carbons as Benzocaine-Delivery Platforms
by: Joanna Goscianska, et al.
Published: (2021-04-01)

Synthesis of Magnetic Halloysite Composites for the Effective Removal of Tetracycline Hydrochloride from Aqueous Solutions
by: Weisheng Guan, et al.
Published: (2012-07-01)

Spectrophotometric determination of Aspirin and Pyridoxine Hydrochloride using 9- Chloroacridin reagent in aqueous solution
by: Intisar Shehab, et al.
Published: (2020-03-01)

Ultrasonic Studies of Some Biomolecules in Aqueous Guanidine Hydrochloride Solutions at 298.15 K
by: R. Palani, et al.
Published: (2011-01-01)

Spectrophotometric Assay of Phenylephrine hydrochloride in Pharmaceutical Formulation with Alizarin Red sulphonate in Aqueous Solution
by: Thabit Al-Ghabsha, et al.
Published: (2013-12-01)

<b>The effect of β-cyclodextrin in the photochemical stability of propranolol hydrochloride in aqueous solution<b>
by: Tathiane Lilian Ansolin, et al.
Published: (2014-04-01)

Cannot write session to /tmp/vufind_sessions/sess_4jvuko9pc00hoq225g5l3vqlgb