Stability of Epidoxorubicin Hydrochloride in Aqueous Solutions: Experimental and Theoretical Studies

The first-order degradation kinetics of epidoxorubicin were investigated as a function of pH, temperature, and buffers concentrations. The degradation was followed by HPLC. Buffer catalysis was observed in acetate and phosphate buffers. The pH-rate profiles were obtained at 333, 343, 353, and 363 K....

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Main Authors: Agnieszka Sobczak, Monika A. Lesniewska-Kowiel, Izabela Muszalska, Artur Firlej, Judyta Cielecka-Piontek, Szymon Tomczak, Bolesław Barszcz, Irena Oszczapowicz, Anna Jelińska
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2017/8107140