Involvement of Hydrogen Peroxide in Safingol-Induced Endonuclease G-Mediated Apoptosis of Squamous Cell Carcinoma Cells

Involvement of Hydrogen Peroxide in Safingol-Induced Endonuclease G-Mediated Apoptosis of Squamous Cell Carcinoma Cells

Safingol, a L-threo-dihydrosphingosine, induced the nuclear translocation of a mitochondrial apoptogenic mediator—endonuclease G (endo G)—and apoptosis of human oral squamous cell carcinoma (SCC) cells. Upstream mediators remain largely unknown. The levels of hydrogen peroxide (H2O2) in cultured ora...

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Bibliographic Details
Main Authors: Masakazu Hamada, Ken Wakabayashi, Atsushi Masui, Soichi Iwai, Tomoaki Imai, Yoshiaki Yura
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:International Journal of Molecular Sciences
Subjects:
safingol
hydrogen peroxide
apoptosis
endonuclease G
Online Access:http://www.mdpi.com/1422-0067/15/2/2660

Internet

http://www.mdpi.com/1422-0067/15/2/2660

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