Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus

Mutations in the neuronal voltage-gated sodium channel genes SCN1A and SCN2A are associated with inherited epilepsies, including genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome (severe myoclonic epilepsy of infancy). The clinical presentation and severity of these epilepsies...

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Bibliographic Details
Main Authors: Nicole A. Hawkins, Melinda S. Martin, Wayne N. Frankel, Jennifer A. Kearney, Andrew Escayg
Format: Article
Language:English
Published: Elsevier 2011-03-01
Series:Neurobiology of Disease
Subjects:
Epilepsy
Sodium channel
Potassium channel
Modifier
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110003918

Internet

http://www.sciencedirect.com/science/article/pii/S0969996110003918

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