Human Wharton’s Jelly Stem Cell Secretions Inhibit Human Leukemic Cell Line K562 in vitro by Inducing Cell Cycle Arrest and Apoptosis

Human Wharton’s Jelly Stem Cell Secretions Inhibit Human Leukemic Cell Line K562 in vitro by Inducing Cell Cycle Arrest and Apoptosis

Emerging resistance to the tyrosine kinase inhibitors that target the BCR-ABL1 oncoprotein has prompted research for novel therapeutics against chronic myeloid leukemia (CML). Herein, we evaluated the tumor inhibitory properties of the human Wharton’s jelly stem cells (hWJSCs) co-culture (hWJSC-CC)...

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Bibliographic Details
Main Authors: Muneerah A. H. Huwaikem, Gauthaman Kalamegam, Ghadeer Alrefaei, Farid Ahmed, Roaa Kadam, Talal Qadah, Khalid H. W. Sait, Peter N. Pushparaj
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
chronic myeloid leukemia
human Wharton’s jelly stem cells
cell cycle
apoptosis
gene expression
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.614988/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.614988/full

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