Disrupting VEGF–VEGFR1 Interaction: De Novo Designed Linear Helical Peptides to Mimic the VEGF13-25 Fragment

Disrupting VEGF–VEGFR1 Interaction: De Novo Designed Linear Helical Peptides to Mimic the VEGF13-25 Fragment

The interaction between vascular endothelial growth factor (VEGF) and its receptors (VEGFR) has important implications in angiogenesis and cancer, which moved us to search for peptide derivatives able to block this protein–protein interaction. In a previous work we had described a collection of line...

Full description

Bibliographic Details
Main Authors: Beatriz Balsera, M. Ángeles Bonache, Marie Reille-Seroussi, Nathalie Gagey-Eilstein, Michel Vidal, Rosario González-Muñiz, María Jesús Pérez de Vega
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Molecules
Subjects:
peptides
α-helix
protein–protein interactions
VEGF-VEGFR1
angiogenesis
Online Access:https://www.mdpi.com/1420-3049/22/11/1846

Internet

https://www.mdpi.com/1420-3049/22/11/1846

Similar Items