Cryptococcus neoformans Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model

Cryptococcus neoformans Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model

The number of deaths from cryptococcal meningitis is around 180,000 per year. The disease is the second leading cause of mortality among individuals with AIDS. Antifungal treatment is costly and associated with adverse effects and resistance, evidencing the urgency of development of both therapeutic...

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Bibliographic Details
Main Authors: Ana Caroline Colombo, Antonella Rella, Tyler Normile, Luna S. Joffe, Patricia M. Tavares, Glauber R. de S. Araújo, Susana Frases, Erika P. Orner, Amir M. Farnoud, Bettina C. Fries, Brian Sheridan, Leonardo Nimrichter, Marcio L. Rodrigues, Maurizio Del Poeta
Format: Article
Language:English
Published: American Society for Microbiology 2019-04-01
Series:mBio
Subjects:
Cryptococcus neoformans
capsule
extracellular vesicles
fungal infection
glucuronoxylomannan
glycolipids
polysaccharides
sterylglucosides
vaccine
vesicles
Online Access:https://doi.org/10.1128/mBio.02909-18

Internet

https://doi.org/10.1128/mBio.02909-18

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