Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions.

Common genetic variants 3' of MC4R within two large linkage disequilibrium (LD) blocks spanning 288 kb have been associated with common and rare forms of obesity. This large association region has not been refined and the relevant DNA segments within the association region have not been identif...

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Bibliographic Details
Main Authors: Daniel S Evans, Melissa A Calton, Mee J Kim, Pui-Yan Kwok, Iva Miljkovic, Tamara Harris, Annemarie Koster, Yongmei Liu, Gregory J Tranah, Nadav Ahituv, Wen-Chi Hsueh, Christian Vaisse
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4018404?pdf=render