In Vitro and In Vivo Pharmacology and Pharmacokinetics of a Human Engineered™ Monoclonal Antibody to Epithelial Cell Adhesion Molecule

In Vitro and In Vivo Pharmacology and Pharmacokinetics of a Human Engineered™ Monoclonal Antibody to Epithelial Cell Adhesion Molecule

ING-1(heMAb), a Human Engineered™ monoclonal antibody to epithelial cell adhesion molecule (Ep-CAM ), was evaluated for its in vitro and in vivo activity. The dissociation constant of ING-1(heMAb) for binding to Ep-CAM on HT-29 human colon tumor cells was 2 to 5 nM, similar to chimeric ING-1. In an...

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Bibliographic Details
Main Authors: W. Steve Ammons, Robert J. Bauer, Arnold H. Horwitz, Zhi J. Chen, Eddie Bautista, Harry H. Ruan, Marina Abramova, Kristen R. Scott, Russell L. Dedrick
Format: Article
Language:English
Published: Elsevier 2003-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
ING-1
ADCC
xenograft
pharmacokinetics
anti-Ep-CAM
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558603800064

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http://www.sciencedirect.com/science/article/pii/S1476558603800064

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