The SIN3A/HDAC Corepressor Complex Functionally Cooperates with NANOG to Promote Pluripotency

The SIN3A/HDAC Corepressor Complex Functionally Cooperates with NANOG to Promote Pluripotency

Although SIN3A is required for the survival of early embryos and embryonic stem cells (ESCs), the role of SIN3A in the maintenance and establishment of pluripotency remains unclear. Here, we find that the SIN3A/HDAC corepressor complex maintains ESC pluripotency and promotes the generation of induce...

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Bibliographic Details
Main Authors: Arven Saunders, Xin Huang, Miguel Fidalgo, Michael H. Reimer, Jr., Francesco Faiola, Junjun Ding, Carlos Sánchez-Priego, Diana Guallar, Carmen Sáenz, Dan Li, Jianlong Wang
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
SIN3A
HDAC1
HDAC2
VPA
pre-iPSCs
iPSCs
EpiSCs
ESCs
SIN3B
TET1/2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717301122

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http://www.sciencedirect.com/science/article/pii/S2211124717301122

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