Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis

Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis

Abstract Background The progressive neurodegenerative disorder multiple system atrophy (MSA) is characterized by α-synuclein-positive (oligodendro-) glial cytoplasmic inclusions (GCIs). A connection between the abnormal accumulation of α-synuclein in GCIs and disease initiation and progression has b...

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Bibliographic Details
Main Authors: Lisa Fellner, Edith Buchinger, Dominik Brueck, Regina Irschick, Gregor K. Wenning, Nadia Stefanova
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Neuroscience
Subjects:
Macroautophagy
Multiple system atrophy
α-Synuclein
Oligodendroglia
Glial cytoplasmic inclusions
Online Access:http://link.springer.com/article/10.1186/s12868-018-0431-2

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http://link.springer.com/article/10.1186/s12868-018-0431-2

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