Combination of Salvia miltiorrhiza and ligustrazine attenuates bleomycin-induced pulmonary fibrosis in rats via modulating TNF-α and TGF-β

Combination of Salvia miltiorrhiza and ligustrazine attenuates bleomycin-induced pulmonary fibrosis in rats via modulating TNF-α and TGF-β

Abstract Background Idiopathic pulmonary fibrosis (IPF), a chronic, progressive, fibrosing interstitial lung disease, is associated with extremely poor prognosis, and lacks effective treatment. The frequently used immunosuppressive therapies such as dexamethasone (DEX) are often associated with side...

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Bibliographic Details
Main Authors: Chengliang Huang, Xu Wu, Shengpeng Wang, Wenjun Wang, Fang Guo, Yuanyuan Chen, Bi Pan, Ming Zhang, Xianming Fan
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Chinese Medicine
Subjects:
Ligustrazine
Pulmonary fibrosis
Salvia miltiorrhiza
SMAD4
TNF-α
Online Access:http://link.springer.com/article/10.1186/s13020-018-0194-9

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http://link.springer.com/article/10.1186/s13020-018-0194-9

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