GRP78-Mediated Signaling Contributes to Axonal Growth Resulting in Motor Function Recovery in Spinal Cord-Injured Mice

GRP78-Mediated Signaling Contributes to Axonal Growth Resulting in Motor Function Recovery in Spinal Cord-Injured Mice

Promoting axonal growth is essential for repairing damaged neuronal connections and motor function in spinal cord injury (SCI). Neuroleukin (NLK) exerts axonal growth activity in vitro and in vivo, but the mechanism remains unclear. This study reveals that the 78-kDa glucose-regulated protein (GRP78...

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Bibliographic Details
Main Authors: Yoshitaka Tanie, Tomoharu Kuboyama, Chihiro Tohda
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
neuroleukin
axonal growth
78 kDa glucose regulated protein
spinal cord injury
recovery of motor function
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00789/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00789/full

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