Design and Optimisation of Bioactive Cyclic Peptides: Generation of a Down-Regulator of TNF Secretion

Design and Optimisation of Bioactive Cyclic Peptides: Generation of a Down-Regulator of TNF Secretion

Although strong binding interactions between protein receptor and ligand do not require the participation of a large number of amino acids in either site, short peptide chains are generally poor at recreating the types of protein-protein interactions which take place during cell recognition and sign...

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Bibliographic Details
Main Authors: Roger New, Gurpal S. Bansal, Malgorzata Dryjska, Michal Bogus, Patricia Green, Marc Feldmann, Fionula Brennan
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:Molecules
Subjects:
cyclic peptide
TNF
interleukin 6
rheumatoid arthritis
lipo amino acid
Online Access:http://www.mdpi.com/1420-3049/19/12/21529

Internet

http://www.mdpi.com/1420-3049/19/12/21529

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