Hsa-miR-4277 Decelerates the Metabolism or Clearance of Sorafenib in HCC Cells and Enhances the Sensitivity of HCC Cells to Sorafenib by Targeting cyp3a4

Hsa-miR-4277 Decelerates the Metabolism or Clearance of Sorafenib in HCC Cells and Enhances the Sensitivity of HCC Cells to Sorafenib by Targeting cyp3a4

Increasing evidence has shown that the metabolism and clearance of molecular targeted agents, such as sorafenib, plays an important role in mediating the resistance of HCC cells to these agents. Metabolism of sorafenib is performed by oxidative metabolism, which is initially mediated by CYP3A4. Thus...

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Bibliographic Details
Main Authors: Xi He, Huiwei Sun, Qiyu Jiang, Yantao Chai, Xiaojuan Li, Zhijie Wang, Bing Zhu, Shaoli You, Boan Li, Junfeng Hao, Shaojie Xin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
advanced hepatocellular carcinoma
cytochrome P450 3A4
miR-4277
chemoresistance
sorafenib
metabolism or clearance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.735447/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.735447/full

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