Patient with Recurrent Glioblastoma Responding Favorably to Ketogenic Diet Combined with Intranasal Delivery of Perillyl Alcohol: A Case Report and Literature Review

Patient with Recurrent Glioblastoma Responding Favorably to Ketogenic Diet Combined with Intranasal Delivery of Perillyl Alcohol: A Case Report and Literature Review

Abstract Introduction Monoterpene perillyl alcohol (POH) is cytotoxic to temozolomide-resistant glioma cells, regardless of its O6-methylguanine-methyltransferase (MGMT) promoter methylation status. Moreover, adherence to a ketogenic diet (KD) produced successful outcomes in preclinical...

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Bibliographic Details
Main Authors: Juliana Guimarães Santos, Wanise Maria Souza Da Cruz, Axel H. Schönthal, Marcela D'alincourt Salazar, Cristina Asvolinsque Pantaleão Fontes, Thereza Quirico-Santos, Clovis Orlando da Fonseca
Format: Article
Language:English
Published: Thieme Revinter Publicações Ltda. 2017-08-01
Series:Brazilian Neurosurgery
Subjects:
ketogenic diet
perillyl alcohol
intranasal administration
glioblastoma multiforme
combination therapy
drug resistance
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1605588

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1605588

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