Synthesis of Acridine-based DNA Bis-intercalating Agents

Methods for the synthesis of N1, N8-bis(9-acridinyl)-N4-(4-hydroxybenzyl)-spermidine and N1, N7-(hydroxybenzyl)-bis-(3-aminopropyl)amine were investigated. Thus monocyanoethylation of 4-methoxybenzylamine followed by treatment with 4-chlorobutyronitrile gave the dinitrile N-(2-cyanoethyl)-N-(3-cyano...

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Bibliographic Details
Main Authors: P. Mack, David P. Kelly, Gerard P. Moloney
Format: Article
Language:English
Published: MDPI AG 2001-02-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/6/3/230/