Hypermethylation of the Gene Coding for PGC-1α in Peripheral Blood Leukocytes of Patients With Parkinson’s Disease

Hypermethylation of the Gene Coding for PGC-1α in Peripheral Blood Leukocytes of Patients With Parkinson’s Disease

Decreased expression of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) is implicated in the pathophysiology of Parkinson’s disease (PD). However, our understanding of the mechanism regulating the PGC-1α expression is still limited. We sought to determine whether the epigene...

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Bibliographic Details
Main Authors: Xiaodong Yang, Shaoqing Xu, Yiwei Qian, Xiaoqin He, Shengdi Chen, Qin Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson’s disease
DNA methylation
PGC-1α
variants
mRNA expression
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00097/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00097/full

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