Calreticulin promotes EMT in pancreatic cancer via mediating Ca2+ dependent acute and chronic endoplasmic reticulum stress

Calreticulin promotes EMT in pancreatic cancer via mediating Ca2+ dependent acute and chronic endoplasmic reticulum stress

Abstract Background Our previous study showed that calreticulin (CRT) promoted EGF-induced epithelial-mesenchymal transition (EMT) in pancreatic cancer (PC) via Integrin/EGFR-ERK/MAPK signaling. We next investigated the novel signal pathway and molecular mechanism involving the oncogenic role of CRT...

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Bibliographic Details
Main Authors: Weiwei Sheng, Guosen Wang, Jingtong Tang, Xiaoyang Shi, Rongxian Cao, Jian Sun, Yi Heng Lin, Chao Jia, Chuanping Chen, Jianping Zhou, Ming Dong
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Calreticulin
Intracellular free Ca2 +
Endoplasmic reticulum stress
IRE1α
Epithelial mesenchymal transition
Pancreatic cancer
Online Access:http://link.springer.com/article/10.1186/s13046-020-01702-y

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http://link.springer.com/article/10.1186/s13046-020-01702-y

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