Locked and Unlocked Nucleosides in Functional Nucleic Acids
Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-05-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/6/4511/ |
| Summary: | Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes. |
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| ISSN: | 1420-3049 |