AR12286 Alleviates TGF-β-Related Myofibroblast Transdifferentiation and Reduces Fibrosis after Glaucoma Filtration Surgery

AR12286 Alleviates TGF-β-Related Myofibroblast Transdifferentiation and Reduces Fibrosis after Glaucoma Filtration Surgery

Scar formation can cause the failure of glaucoma filtration surgery. We investigated the effect of AR12286, a selective Rho-associated kinase inhibitor, on myofibroblast transdifferentiation and intraocular pressure assessment in rabbit glaucoma filtration surgery models. Cell migration and collagen...

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Bibliographic Details
Main Authors: Wen-Sheng Cheng, Ching-Long Chen, Jiann-Torng Chen, Le-Tien Lin, Shu-I Pao, Yi-Hao Chen, Da-Wen Lu
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
human conjunctival fibroblast
AR12286
TGF-β
α-SMA
SMAD
glaucoma filtration surgery
Online Access:https://www.mdpi.com/1420-3049/25/19/4422

Internet

https://www.mdpi.com/1420-3049/25/19/4422

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