Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice

Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice

Sepsis is one of the most prevalent diseases in the world. The development of cardiac dysfunction in sepsis results in an increase of mortality. It is known that Bruton's tyrosine kinase (BTK) plays a role in toll-like receptor signaling and NLRP3 inflammasome activation, two key components in...

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Bibliographic Details
Main Authors: Caroline E. O'Riordan, Gareth S. D. Purvis, Debora Collotta, Fausto Chiazza, Bianka Wissuwa, Sura Al Zoubi, Lara Stiehler, Lukas Martin, Sina M. Coldewey, Massimo Collino, Christoph Thiemermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
Bruton's tyrosine kinase (BTK)
sepsis
cardiac dysfunction
ibrutinib
acalabrutinib
NLRP3
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02129/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02129/full

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