Protection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation.

Protection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation.

Inhibition of glucose oxidation during initial reperfusion confers protection against ischemia-reperfusion (IR) injury in the heart. Mitochondrial metabolism is altered with progression of type 2 diabetes (T2DM). We hypothesized that the metabolic alterations present at onset of T2DM induce cardiopr...

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Bibliographic Details
Main Authors: Jonas Agerlund Povlsen, Bo Løfgren, Christian Dalgas, Rune Isak Dupont Birkler, Mogens Johannsen, Nicolaj Brejnholt Støttrup, Hans Erik Bøtker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3660588?pdf=render

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http://europepmc.org/articles/PMC3660588?pdf=render

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