LINE-1 hypomethylation during primary colon cancer progression.

BACKGROUND: Methylation levels of genomic repeats such as long interspersed nucleotide elements (LINE-1) are representative of global methylation status and play an important role in maintenance of genomic stability. The objective of the study was to assess LINE-1 methylation status in colorectal ca...

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Bibliographic Details
Main Authors: Eiji Sunami, Michiel de Maat, Anna Vu, Roderick R Turner, Dave S B Hoon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3077413?pdf=render