Diagnostic Profiling of the Human Public IgM Repertoire With Scalable Mimotope Libraries

Diagnostic Profiling of the Human Public IgM Repertoire With Scalable Mimotope Libraries

Specific antibody reactivities are routinely used as biomarkers, but the antibody repertoire reactivity (igome) profiles are still neglected. Here, we propose rationally designed peptide arrays as efficient probes for these system level biomarkers. Most IgM antibodies are characterized by few somati...

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Bibliographic Details
Main Authors: Anastas Pashov, Velizar Shivarov, Maya Hadzhieva, Victor Kostov, Dilyan Ferdinandov, Karen-Marie Heintz, Shina Pashova, Milena Todorova, Tchavdar Vassilev, Thomas Kieber-Emmons, Leonardo A. Meza-Zepeda, Eivind Hovig
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
diagnostic
phage display
antibody repertoire
mimotope
systems immunology
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02796/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02796/full

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