Oct4 Regulates the Transition of Cancer Stem-Like Cells to Tumor Endothelial-Like Cells in Human Liver Cancer

Oct4 Regulates the Transition of Cancer Stem-Like Cells to Tumor Endothelial-Like Cells in Human Liver Cancer

Octamer-binding transcription factor 4 (Oct4) has been recently implicated as a proangiogenic regulator in several induced pluripotent stem cells (iPSCs), however, its role in cancer stem-like cells (CSCs) remain unclear. We report here that Oct4 participates in tumor vasculogenesis in liver CSCs (L...

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Bibliographic Details
Main Authors: Hong-Lin Liu, Hong-ting Tang, Han-lin Yang, Ting-Ting Deng, Ya-Ping Xu, Shi-Qing Xu, Liang Peng, Zai Wang, Qing Fang, Xiao-Yan Kuang, Qin-Shan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Oct4
vasculogenesis
cancer stem-like cells
endothelial trans-differentiation
transition
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.563316/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.563316/full

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