SHANK3 Downregulation in the Ventral Tegmental Area Accelerates the Extinction of Contextual Associations Induced by Juvenile Non-familiar Conspecific Interaction

SHANK3 Downregulation in the Ventral Tegmental Area Accelerates the Extinction of Contextual Associations Induced by Juvenile Non-familiar Conspecific Interaction

Haploinsufficiency of the SHANK3 gene, encoding for a scaffolding protein located in the postsynaptic density of glutamatergic synapse, has been linked to forms of autism spectrum disorders (ASDs). It has been shown that SHANK3 controls the maturation of social reward circuits in the ventral tegment...

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Bibliographic Details
Main Authors: Sebastiano Bariselli, Alessandro Contestabile, Stamatina Tzanoulinou, Stefano Musardo, Camilla Bellone
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
conditioned place preference
social novelty
VTA
Shank3
isolation
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00360/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00360/full

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