Calcium channel blocker enhances beneficial effects of an angiotensin II AT1 receptor blocker against cerebrovascular-renal injury in type 2 diabetic mice.

Recent clinical trials have demonstrated that combination therapy with renin-angiotensin system inhibitors plus calcium channel blockers (CCBs) elicits beneficial effects on cardiovascular and renal events in hypertensive patients with high cardiovascular risks. In the present study, we hypothesized...

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Bibliographic Details
Main Authors: Kazi Rafiq, Shamshad J Sherajee, Hirofumi Hitomi, Daisuke Nakano, Hiroyuki Kobori, Koji Ohmori, Hirohito Mori, Hideki Kobara, Tsutomu Masaki, Masakazu Kohno, Akira Nishiyama
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3858271?pdf=render