PITX2 Loss-of-Function Mutation Contributes to Congenital Endocardial Cushion Defect and Axenfeld-Rieger Syndrome.

PITX2 Loss-of-Function Mutation Contributes to Congenital Endocardial Cushion Defect and Axenfeld-Rieger Syndrome.

Congenital heart disease (CHD), the most common type of birth defect, is still the leading non-infectious cause of infant morbidity and mortality in humans. Aggregating evidence demonstrates that genetic defects are involved in the pathogenesis of CHD. However, CHD is genetically heterogeneous and t...

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Bibliographic Details
Main Authors: Cui-Mei Zhao, Lu-Ying Peng, Li Li, Xing-Yuan Liu, Juan Wang, Xian-Ling Zhang, Fang Yuan, Ruo-Gu Li, Xing-Biao Qiu, Yi-Qing Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4404345?pdf=render

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http://europepmc.org/articles/PMC4404345?pdf=render

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