Protective Effects of Simvastatin on Endotoxin-Induced Acute Kidney Injury through Activation of Tubular Epithelial Cells’ Survival and Hindering Cytochrome C-Mediated Apoptosis

Protective Effects of Simvastatin on Endotoxin-Induced Acute Kidney Injury through Activation of Tubular Epithelial Cells’ Survival and Hindering Cytochrome C-Mediated Apoptosis

Increasing evidence suggests that apoptosis of tubular cells and renal inflammation mainly determine the outcome of sepsis-associated acute kidney injury (AKI). The study aim was to investigate the molecular mechanism involved in the renoprotective effects of simvastatin in endotoxin (lipopolysaccha...

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Bibliographic Details
Main Authors: Lana Nežić, Ranko Škrbić, Ljiljana Amidžić, Radoslav Gajanin, Zoran Milovanović, Eugenie Nepovimova, Kamil Kuča, Vesna Jaćević
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
simvastatin
endotoxin
tubular apoptosis
cytochrome C
Bcl-XL
survivin
Online Access:https://www.mdpi.com/1422-0067/21/19/7236

Internet

https://www.mdpi.com/1422-0067/21/19/7236

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